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KMID : 1140120110160020141
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Cancer Prevention Research
2011 Volume.16 No. 2 p.141 ~ p.146
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Montiporyne A Induces Apoptosis in SK-MEL-2 Human Melanoma Cells
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Kim Nam-Deuk
Lee kyoung-Mi
Hossain Mohammad Akbar
Kim Dong-Hwan
Jang Jung-Yoon
Jung Jee-H.
Yoon Jeong-Hyun
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Abstract
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In this study, we investigated the effects of montiporyne A which was isolated from the stony coral Montipora species, on the proliferation of SK-MEL-2 human skin melanoma cells (mutant p53). Twenty-four hour treatment of montiporyne A inhibited the growth of melanoma cells and induced apoptotic cell death. This montiporyne A-induced apoptosis in the SK-MEL-2 cells was closely linked with the down-regulation of Bcl-2 protein expression and the cleavage of poly(ADP-ribose) polymerase. Montiporyne A treatment also caused a marked increase in the level of p21WAF1/CIP1 protein in a p53-independent manner. Based on our data, montiporyne A can be considered as a good candidate for an effective chemotherapeutic agent inducing apoptosis of cancer cells, although further study will be needed to be confirm.
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KEYWORD
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Montiporyne A, Human skin cancer cells, Apoptosis
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